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TRACE Analysis

TRACE (Topological Ring And Cage Enumeration) is a graph-based algorithm for detecting hydrogen-bonded cage structures in clathrate hydrates.

How It Works

  1. H-bond Detection: Identifies hydrogen bonds based on O-O distance (default: 3.5 Å)
  2. Ring Finding: Enumerates all 5- and 6-membered rings in the H-bond network
  3. Cage Assembly: Combines rings into complete polyhedral cages
  4. Classification: Labels cages by their face signature (e.g., 5¹²6²)

Detected Cage Types

NotationNameStructure Type
5¹²DodecahedronsI small cage
5¹²6²TetrakaidecahedronsI large cage
5¹²6⁴HexakaidecahedronsII large cage
5¹²6⁸IcosahedronsH large cage

Running TRACE

  1. Upload your .gro file
  2. Navigate to the ANALYZE tab
  3. Select TRACE algorithm
  4. Click RUN TRACE

Terminology

  • SEC (Standard Edge-saturated Cage): Complete cage with all H-bonds satisfied
  • nSEC (Non-Standard Edge-saturated Cage): Cage with unusual topology
  • IC (Incomplete Cage): Partially formed cage structure

Reference

Hsu, Y.-C. & Lin, S.-T. (2025). TRACE: Topological Ring and Cage Enumeration. Journal of Chemical Theory and Computation. DOI: 10.1021/acs.jctc.5c01459